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Archive | ISSUE: , Volume: Jul-Sep-2025

CHALLENGES IN DIAGNOSING AND MANAGING SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SYNDROME, A CASE REPORT


Author:Anthony EC , Ugwuanyi O, Uwanuruochi V , Uwanuruochi K

published date:2025-Sep-07

FULL TEXT in - | page 79-81

Abstract

Background: Diagnosis and management of syndrome of inappropriate antidiuretic hormone is challenging and impaired by 

cost and availability issues.

Case presentation: An 81-year-old man who had features of chronic obstructive airway disease and cor pulmonale, 

subsequently developing recurrent seizures and severe persistent hyponatraemia. We discuss measures that will improve 

diagnosis as well as management of syndrome of inappropriate antidiuretic hormone (SAIDH) in local settings. 

Conclusion: The challenges to diagnosis and management of syndrome of inappropriate antidiuretic hormone syndrome 

should be appreciated

Key words: Syndrome of inappropriate antidiuretic hormone syndrome, Severe hyponatraemia, Recurrent seizures.Cite this article: Anthony EC, Ugwuanyi O, Uwanuruochi V, Uwanuruochi K. Challenges in diagnosing and managing Syndrome of Inappropriate Antidiuretic Hormone Syndrome, A case report. Niger Delta J Med Med Res. 2025;4(3):79–81.

 

Keywords: Syndrome of inappropriate antidiuretic hormone syndrome, Severe hyponatraemia, Recurrent seizures.,,

References

 

1. Van Amelsvoort T, Bakshi R, Devaux CB, Schwabe S. Hyponatremia associated with carbamazepine and oxcarbazepine therapy: a review. Epilepsia. 1994 Jan-Feb;35(1):181-188. 
2. Smith, Haley D; Kelly, Cheri W. PA-C, MS; DiCocco, Margaret MS. Syndrome of inappropriate antidiuretic hormone production caused by multiple factors. JAAPA 2015:28(12):1. 
3. Fenske W, Störk S, Koschker AC, Blechschmidt A, Lorenz D, Wortmann S, et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab. 2008;93:2991–2997. 
4. Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M, et al. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. J Am Soc Nephrol. 2014 Oct;25(10):2376-2383. 
5. Schwartz WB, Bennett W, Curelop S, Bartter FC. Syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957; 23: 529–542.
6. Berl T, Robertson GL. Pathophysiology of water metabolism. In: Brenner B.M. (ed.), The Kidney.Philadelphia: Saunders, 2000 pp; 866–924.
7. Pillai BP, Unnikrishnan AG, Pavithran PV. Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder. Indian J Endocrinol Metab. 2011 Sep; 15 Suppl 3(Suppl3):S208-215.
8. Forrest JN, Cox M, Hong C, Morrison G, Bia M, Singer I. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med.1978; 298: 173–177
9. Annane D, Decaux G, Smith N. Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia. Am J Med Sci. 2009; 337: 28–36
10. Pirklbauer M. Hemodialysis treatment in patients with severe electrolyte disorders: Management of hyperkalemia and hyponatremia. Hemodial Int. 2020 Jul; 24(3):282-289. 
11. Decaux G. Long-term treatment of patients with inappropriate secretion of antidiuretic hormone by the vasopressin receptor antagonist conivaptan, urea, or furosemide. Am J Med. 2001; 110: 582–584.
12. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH. Hyponatremia treatment guidelines 2007: Expert panel recommendations. Am J Med.2007;120:S1–21. 
13. Al-Salman J, Kemp D, Randall D. Hyponatremia. West J Med. 2002 May;176(3):173-6. 
14. Grant P, Ayuk J, Bouloux PM, Cohen M, Cranston I, Murray RD, et al. The diagnosis and management of inpatient hyponatraemia and SIADH. Eur J Clin Invest. 2015 Aug;45(8):888-894.
15. Verbalis JG, Greenberg A, Burst V, Haymann JP, Johannsson G, Peri A, et al. Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion. Am J Med. 2016 May;129(5):537.e9-
537.e23.81 | 

FULL TEXT in - | page 79-81

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