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Archive | ISSUE: , Volume: Apr-Jun-2025

EVALUATION OF THE EFFECTS OF PLEUROTUS OSTEATUS AND CALOCYBE INDICA ON THE LIVER AND KIDNEY FUNCTION OF WISTAR ALBINO RATS


Author:Deborah Etin-Osa, Brenda Isichei-Ukah, Endurance Ophori

published date:2025-Oct-24

FULL TEXT in - | page 52-61

Abstract

Background: The search for safe, natural compounds with therapeutic potential has led to increased interest in edible mushrooms such as Calocybe indica and Pleurotus ostreatus. These mushrooms are rich in bioactive compounds and arewidely consumed, yet their safety profiles, particularly regarding liver and kidney function, require further investigation. This

 study evaluates the acute toxicity, as well as hepatic and renal effects, of ethanol extracts of these mushrooms in Wistar albino rats to assess their suitability for therapeutic use. This study is aimed at determining the acute toxicity, liver function and function effects of ethanol extract of C. indica and P. ostreatus on Wistar albino rats.

Materials and Methods: A total of 34 rats divided into seven treatment groups and one control group where (n=4) were used in this study. Varying doses (5,10,15 mg/ml) of each mushroom were fed to Wistar albino rats for 14 days. Acute toxicity test, liver function test and electrolytes, urea and creatinine tests were conducted and the parameter closely examined.

Results: The liver function test results showed 146.5, 74.75, 324.38, 0.25, 0.14, 6.99, 3.57 for indica and 148.4, 65.94, 310.31, 0.24, 0.14, 6.89, 3.30 for P. ostreatus treated rats for aspartate aminotransferase, alanine aminotransferase, alkaline phosphates, total bilirum, direct bilirum, total protein, albumin respectively. The electrolytes, urea, and creatinine results

were 32.53, 137.56, 4.19, 23.06, 101.94, 0.50 for C. indica and 29.38, 137.98, 3.94, 23.63, 100.69 and 0.49 P. ostreatus respectively.

Conclusion: All these were statistically significant when compared with the control values but no statistically significant difference was recorded when comparing the two mushroom samples vis-à-vis each other (P > 0.05). Conclusively, these findings suggest that C. indica and P. ostreatus have minimal toxicity warranting their consideration for optimized therapeutic efficacy.

Keywords: Liver function, Hepatotoxic, Kidney function, Toxicity, Hepatoprotective

 

Cite this article: Etin-Osa D, Isichei-Ukah B, Ophori E. Evaluation of the effects of Pleurotus osteatus and Calocybe indica on

the liver and kidney function of wistar albino rats. Niger Delta J Med Med Res. 2025;4(2):52–61.

Keywords: Liver function, Hepatotoxic, Kidney function, Toxicity, Hepatoprotective

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